1999-2000 Academic All-State Nominees
Boys
| PLAYER | SCHOOL | COACH |
| Robert Allen | Lee's Summit North | Kevin Harrison |
| Luke Arthur | Houston | Charlie Malam |
| Levi Bollinger | Jackson | Steve Burk |
| Jeff Brown | Salisbury | Kenny Wyatt |
| Michael Brueggenjohann | Warrenton | Rich Barton |
| Ryan Bubalo | Blue Springs South | Gil Hanlin |
| Cale Davis | Putnam County | Robert Johnson |
| Tony Dorsett | West County | Kenny Ash |
| Kent Dryer | Liberty | Roger Stirtz |
| Joe Duchek | DeSmet | Bob Steiner |
| Frank Fiock | S.L.U.H. | Don Maurer |
| Brian Fuller | Lawson | Brad Smith |
| Aaron Gage | Lamar | Mark Fleming |
| Matt Gildehaus | Union | Greg Dunigan |
| Jay Gottman | Palmyra | Brad Thompson |
| Matt Gottman | Palmyra | Brad Thompson |
| Shawn Guethle | Dexter | Paul Hale |
| Kirk Henley | Eldon | Cloyce Klein |
| David Hodges | Clayton | Joe Gamlin |
| Steve Hopkins | Rolla | Jim Pritchett |
| Jeff Kennedy | Houston | Charlie Malam |
| Bob Keppel | DeSmet | Bob Steiner |
| Brett Kicker | Maryville | Mike Kuwitzky |
| Jim Larson | Pembroke Hill | Alan Mills |
| Michael Lichte | Lexington | Jim Hofstetter |
| Chris Mallonee | Logan-Rogersville | Rod Gorman |
| Brian McVey | Butler | Steven Miller |
| Aaron Mueller | Lutheran North | Kirk Mueller |
| Jeff Muir | New Haven | Ray Steinhoff |
| Jason Poe | Republic | Jeff Schnakenberg |
| Jarrod Sanderson | Holden | Gary Manning |
| Michael Scarey | Climax Springs | Charles Jameson |
| Mark Sears | Lindbergh | Ken Libby |
| Reid Stephens | Chillicothe | Chad Snyder |
| Jared Stockton | Crest Ridge | Rick Schmidt |
| Josh Taylor | Lexington | Jim Hofstetter |
| Jeremy Teeple | Versailles | Kent Champerlain |
| Kelly Turner | Willard | Sean Williamson |
| Anand Twells | Clayton | Joe Gamlin |
| Paul Van Leer | Union | Greg Dunnigan |
| Mark Verslues | Blair Oaks | Gary Verslues |
| Robert Wood | Climax Springs | Charles Jameson |